Endocrine Abstracts

Back ground: Numerous researches indicate that DHEA administration decreases fat mass in human and rodent. We evaluated the effects of DHEA treatment on adiposity. Male Otsuka Long evans fatty (OLETF) rats, hereditary obese type 2 diabetic animals derived from long evans tokushima (LETO) rats. These rats were fed with or without (control) 0.4% DHEA containing food for 52 weeks. Telomere length as a marker of whole cell division in adipose tissue were assessed. Genomic DNA isol...

Background: Primary aldosteronism (PA) has been reported to affect about 10% of patients with essential hypertension. In Western countries, about one third of them have aldosterone-producing adenomas (APA), and mutations of the KCNJ5 gene have recently been identified in approximately 30% of APAs. In contrast, most Japanese (~80%) with PA have APA. Therefore, Japanese PA may have different characteristics from patients in Western countries, and those with mutations of the KCNJ...